Changes of ventricular remodeling in patients with acute myocardial infarction combined with diabetes mellitus after PCI
LI Yaqin
WANG Qianyi
XU Zhanwen
KANG Shixin
WEI Yuan
LI jing
Abstract：Objective To investigate the influence of diabetes mellitus (DM)on ventricular remodeling in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention (PCI).Methods Totally 115 pa-tients with acute ST-segment elevation cardial infarction (STEMI)underwent PCI,including 37 cases of patients with DM (AMI with DM,DMgroup)and 78 cases without DM(AMI without DM,non-DMgroup).The levels of CPK,CK-MB, TC,HDL-C,LDL-C,TG,FPG,and HbAc1 were detected by ELASA.The left ventricular end-diastolic volume (LV-EDV),left ventricular end-systolic volume (LVESV),left ventricular ejection fraction (LVEF),E /A,heart isovolumic relaxation time (IVRT),and wall motion score index (WMSI)was determined by echocardiography in the two groups.The left ventricular remodeling and heart failure,and the incidence rate of ST-segment fall >70% was observed in the two groups.Results All patients were followed up for 6 months.In the DMgroup,1 lost to follow-up,1 died,while in the non-DMgroup,4 lost to follow-up,and 1 died.The rest of 108 patients completed follow-up process.After 6-month PCI, no statistical difference was found in CK,CK-MB,TC,HDL-C,LDL-C,and TG between these two groups (all P >0.05),while significant difference was found in FPG and HbA1c between these two groups (all P <0.05).No statistical difference was found in LVEDV,LVEF,E /A and IVRT between these two groups (all P >0.05).LVESV,WMSI had statitical difference (all P <0.05).Patients with DMshowed a significantly higher rate of ST-segment fall >70% as com-pared with that of patients without DM(17.14% vs 47.94%,P =0.003).Despite a similar incidence of LV remodeling between DMand non-DMgroups (37.14% vs 28.76%,P =0.082),symptoms of heart failure were significantly more in diabetic patients (37.14% vs 19.17%,P =0.008)at 6-month follow-up.Conclusion The risk of heart failure after PCI in patients with acute myocardial infarction and diabetes mellitus is higher than that in non-diabetic patients,but there is no direct relationship with ventricular remodeling.
Keywords：acute myocardial infarctionpercutaneous coronary interventionventricular remodelingdiabetes mellitus
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 19-21 )