Early prediction value of NT-proBNP and NGAL levels for contrast-induced nephropathy in patients with coronary heart disease after stent implantation

DENG Ying; GE Ping; JI Lei

doi:10.3969/j.issn.1002-266X.2017.01.005

Abstract：Objective To observe the changes of serum N terminal pro-B-type natriuretic peptide (NT-proBNP)and urine neutrophil gelatinase-associated lipocalin (NGAL)levels in patients with coronary heart disease after stent implanta-tion and to investigate their early prediction value for contrast-induced nephropathy (CIN).Methods Totally 108 cases of patients with coronary heart disease receiving stent implantation were enrolled.After stent implantation,12 patients had CIN,who were taken as the CIN group.Meanwhile,24 patients without CIN were randomly selected according to the ratio of 2∶1,who were taken as the non-CIN group.The levels of serum creatinine (Cr),blood urea nitrogen (BUN),NT-proBNP and urine NGAL were measured before and after the operation.The early prediction value of serum NT-proBNP and urine NGAL for CIN was estimated by receiver operating characteristic (ROC)curve analysis.Results The levels of ser-um Cr and BUN in the CIN group were significantly higher than those in the non-CIN group at 48 h after operation (all P <0.01).The levels of serum NT-proBNP and urine NGAL in the CIN group were significantly higher than those in the non-CIN group at 3,6,12,24,and 48 h (all P <0.01).The levels of serum NT-proBNP and urine NGAL were positively correlated with serum levels of Cr and BUN at 48 h after operation (all P <0.01).At 12 h after operation,the AUCs were calculated as 0.701 ±0.048 for serum NT-proBNP and 0.825 ±0.029 for urine NGAL,when we combined the serum NT-proBNP and urine NGAL,the AUC was 0.911 ±0.021.At 12 h after the operation,serum NT-proBNP,urine NGAL and the combination of them all had early predictive value for CIN (all P <0.01),besides,the combination of them had higher predictive value for CIN at the early stage (all P <0.01).Conclusion For patients with coronary heart disease after stent implantation,NT-proBNP and NGAL levels can early reflect the kidney function,and have early prediction value for CIN.