Value of peripheral blood cell count in prognosis evaIuation of patients with PGI-DLBCL
ZHAO Pan
YU Yong
WANG Yafei
ZHAO Zhigang
ZHANG Yizhuo
WANG Xiaofang
Abstract：Objective To investigate the value of peripheral blood cell count in the prognosis evaluation of patients with primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL).Methods We retrospectively analyzed the clinical data from patients with newly diagnosed diffuse large B-cell lymphoma who were confirmed by pathology from March 2009 to May 2015.We analyzed the effects of the absolute lymphocyte count (ALC),absolute monocyte count (AMC), absolute lymphocyte count/absolute monocyte count ratio (LMR)and platelet count/absolute lymphocyte count ratio (PLR)on the 5-year overall survival (OS)and progression-free survival (PFS).One hundred and sixty-eight patients were divided into low risk,intermediate risk,intermediate to high risk and high risk groups according to international prog-nostic index (IPI)and aaIPI scores.According to the LMR combined with IPI or aaIPI we divided into three groups:(1) good prognosis group:LMR ≥2.5 and low risk patients,(2)poor prognosis group:LMR <2.5 and high risk patients, (3)general prognosis group:the rest of cases except the above.The OS and PFS was compared between these groups.Re-sults The mean age of all patients was 55 (12-90)years old,and the median follow-up was 25 (8-79)months.Univari-ate analysis showed that ALC,AMC,LMR and PLR were associated with the 5-year OS and PFS (all P <0.05).Multiva-riate analysis showed that 5-year PFS was related with ALC,LMR and LDH,and 5-year OS was related with age and LMR (all P <0.05).There were no significant difference in 5-year OS and 5-year PFS between intermediate to high risk group and high risk group (5-year OS was 32%,23.8%,and 5-year PFS was 20.0%,23.8%).There were statistically signif-icant differences in 5-year OS and 5-year PFS among good prognosis group,general prognosis group and poor prognosis group (5-year OS was 82.8%,60.0% and 14.3%;5-year PFS was 79.3%,53.8% and 14.8%,respectively).Con-clusion At the first visit,the peripheral blood cell count is valuable prognostic factor for patients with PGI-DLBCL,and LMR combined with IPI score is helpful for assessing the risk stratification of PGI-DLBCL in the early period.
Keywords：primary gastrointestinal diffuse large B-cell lymphomaabsolute lymphocyte countabsolute monocyte countplatelet countprognosis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1-5 )