Expression and clinical significance of CD10 and MMP-3 in breast carcinoma tissues

YU Jing; ZHANG Xiaoying; FANG Aiju; DAI Zongyan; SHI Ranran; CHENG Fengfeng

doi:10.3969/j.issn.1002-266X.2016.44.004

Abstract：Objective To detect the expression and clinical significance of CD 10 and matrix metalloproteinase 3 (MMP-3) in breast cancer tissues.Methods The expression of CD10 and MMP-3 was detected in breast cancer tissues (23 cases of ductal carcinoma in situ , 16 cases of microinvasive breast carcinoma , 81 cases of invasive ductal carcinoma and), the control breast tissues (16 cases of normal tissues from healthy people and 24 cases of benign breast tissues ) by immunohistochemistry .The correlations between CD 10 and MMP-3 and between their co-expression and clinicopathological parameters were analyzed .Results The positive rates of CD10 expression in the ductal carcinoma in situ , microinvasive breast carcinoma and invasive ductal carcinoma were 39.1%, 43.8% and 92.6%, the positive rates of MMP-3 were 34.8%, 37.5%, and 86.4%, which were significantly higher than those of the control breast tissues ( 12.5% and 10.0%, all P<0.05).The positive rates of CD10 and MMP-3 expression in the invasive ductal carcinoma were higher than those of the ductal carcinoma in situ and microinvasive breast carcinoma (all P<0.05).The (both) positive rates of CD10 and MMP-3 expression were associated with age , histological type and lymph node involvement (all P<0.05).The expression of CD10 and MMP-3 was positively correlated with each other in the breast carcinoma tissues ( r=0.436, P<0.05).Conclusion The CD10 and MMP-3 expression is increased in the breast cancer tissues , and the expression chan-ges of CD10 and MMP-3 are involved in the development and metastasis of breast carcinoma .