Magnetic resonance diffusion tensor imaging of the fiber of corpus caIIosum in aIcohoI-dependent patients

HONG Shanshan; ZHAO Zhong; HAN Bojun; WANG Qingguang; JIANG Qitao; ZHEN Yongqiang; LIU Dinghua

doi:10.3969/j.issn.1002-266X.2016.43.004

Abstract：Objective To observe the changes in fiber number and structure of corpus callosum in patients with alco-hol dependence through fiber tractography of magnetic resonance diffusion tensor imaging.Methods T1 -weighted magnetic resonance imaging and diffusion tensor imaging were obtained from 48 alcohol-dependent patients (observation group)and 50 cases of age,sex,education year-matched normal controls (control group).The fiber number,fiber fractional anisotro-py (FA),and fiber apparent diffusion coefficient (ADC)of the corpus callosum between the two groups were calculated. Results The fiber number of total corpus callosum in the observation group was 2587 ±654,which was 2875 ±758 in the control group,and significant difference was found between these two groups (P <0.05).The fiber number in anterior one third of corpus callosum in the observation group was 782 ±254,which was 987 ±244 in the control group,there was sig-nificant difference between the two groups (P <0.01).The FA values of total corpus callosum in the observation group were 0.61 ±0.02,which were significantly decreased as compared with than that (0.62 ±0.02)of the control group (P <0.05).FA values of anterior one third of corpus callosum in the observation group (0.59 ±0.03)were decreased as com-pared with that (0.61 ±0.03)of the control group (P <0.01).Compared with the control group [(0.91 ±0.07)×10 -3 mm2 /s],the ADC values of total corpus callosum in the observation group [(0.94 ±0.07) ×10 -3 mm2 /s]were signifi-cantly increased (P <0.05).The ADC values of anterior one third of corpus callosum in the observation group [(0.94 ± 0.06) ×10 -3 mm2 /s]were increased as compared with that [(0.87 ±0.08) ×10 -3 mm2 /s]of the control group (P <0.01).Conclusion Fiber number and structure of the corpus callosum is abnormal in alcohol-dependent patients and this anomaly in the anterior one third of corpus callosum is more obvious.