Pathogenic relation between GLI3 expression and idiopathic congenital talipes equinovarus in Xinjiang Uygur nationality
CHENG Guojie
LYU Faming
WANG Jing
Aikebare Abudurexiti
DONG Haojie
Abstract：Objective To investigate the pathogenic relation between GLI3 expression and idiopathic congenital tali-pes equinovarus (ICTEV)in Xinjiang Uygur nationality.Methods Eighty-four cases of children with ICTEV (observation group,51 cases of Uygur,22 cases of Han)and 39 cases of children with normal foot trauma (control group,25 cases of Uygur,14 cases of Han)were chosen from Xinjiang.Real-time fluorescence quantitative PCR and Western blotting were used to analyze the mRNA and protein levels of GLI3 gene in the muscular tissues.Results The mRNA and protein levels of GLI3 were 0.61 ±0.02,68.72 ±3.05 in the foot muscular tissues in the observation group,while they were 0.07 ± 0.01 and 22.38 ±1.74 in the control group,which were significant different (all P <0.01).The mRNA and protein lev-els of GLI3 in the foot muscular tissues from Uygur children of the observation group were 0.73 ±0.01 and 83.01 ±4.42, while they were 0.40 ±0.02 and 56.85 ±3.50 in Han,which were statistically different (all P <0.05).There were no significant differences in GLI3 mRNA and protein expression levels between the Uygur and Han children in the control group (all P >0.05).Conclusion There is some correlation between GLI3 gene expression and ICTEV,and the Uygur nationality who is easily affected by expression level of GLI3 gene is easier to get ICTEV.
Keywords：idiopathic congenital talipes equinovarusGLI3 geneUygur nationalityHan nationalitypathogenic re-lationXinjiangchild
Publication Date：2016-01-01
Pages：3( 21-23 )