Effects of CYP2D6 gene polymorphism on prognosis of ER-positive breast cancer patients treated with tamoxifen therapy
YU Yang
YOU Wei
LIANG Dong
LYU Feng
YANG Qinheng
ZHANG Bin
Abstract：Objective To discuss the effects of cytochrome P4502D6 (CYP2D6)gene polymorphism on prognosis of estrogen receptor (ER)-positive breast cancer patients treated with tamoxifen (TAM)therapy.Methods From May 2010 to May 2012,CYP2D6 genotype was detected in 106 cases of ER-positive breast cancer patients treated with TAMtherapy by PCR.The relationship between CYP2D6 polymorphism and clinical parameters and prognosis were analyzed by χ2 test and Logistic regression model.Results In 106 cases of ER-positive breast cancer patients treated with TAM therapy,48 cases of Wt/Wt type accounted for 45.3%,42 cases of Wt/*10 type accounted for 39.6%,and 16 cases of *10 /*10 type accounted for 15.1%.χ2 test showed CYP2D6 genotype was not significantly correlated with age (χ2 =0.391,P =0.822),tumor size (χ2 =2.544,P =0.280),histology (χ2 =3.600,P =0.165),TNMstage (χ2 =2.785,P =0.246) and axillary lymph node metastasis (χ2 =2.997,P =0.223).Logistic regression model showed compared with patients with Wt/Wt type and Wt/*10 type,patients with *10 /*10 type had higher risk for 3-year,5-year disease free survival of ER-positive breast cancer patients treated with TAMtherapy.Conclusion The prognosis of *10 /*10 type ER-posi-tive breast cancer patients treated with TAMtherapy is poor,and we can detect CYP2D6 polymorphism before TAMtherapy to use drug rationally.
Keywords：breast carcinomacytochrome P4502D6gene polymorphismtamoxifenestrogen receptor
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 17-20 )