Clinical characteristics and expression of HER2 and SKP2 in Siewert Ⅱand Ⅲ adencarcinoma of gastric esophageal junction
LIU Zhongyuan
ZHANG Li
Abstract：Objective To invesitgate the clinical characteristics and expression of human epidermal growth factor re-ceptor 2 (HER2)and S-phase kinase-associated protein 2 (SKP2)in Siewert Ⅱ and Ⅲ adencarcinoma of gastric esopha-geal junction (AEG).Methods Totally 206 patients with Siewert II or Ⅲ AEG were selected for comparison of the clini-cal characteristics between the two types.The expression of HER2 and SKP2 was detected by immunohistochemistry.The relationships between positive HER2 and SKP2 expression and the clinical pathologic parameters in Siewert Ⅱ and III AEG were analyzed.Results There were statistically significant differences between the two AEG types in tumor size,lymph node metastasis,differentiation grade and TNMstage (all P <0.05).The positive expression rates of HER2 and SKP2 were respectively 32.9% and 41.2% in patient with Siewert II AEG,and 36.3% and 55.4% in patients with Siewert ⅢAEG;there was statistically significant difference in SKP2 positive expression rate between the two groups (P <0.05).A-mong the patients with Siewert II or Ⅲ AEG,there were statistically significant differences in HER2 positive expression rate between those with tumor size <5 cm and ≥5 cm,those with infiltration depth T1 -T2 and T3-T4 ,those with high-moderate and low differentiation,and between those with lymph node metastasis N0-N1 and N2-N3 (all P <0.05).Conclusion Abnormal expression of HER2 and SKP2 could promote the development and progression of AEG,and thus may provide a new approach for early diagnosis and treatment of AEG.
Keywords：adencarcinoma of esophagogastric junctionhuman epidermal growth factor receptor 2S-phase kinase-associated protein 2
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 25-27,30 )