Synergistic effect between hyperhomocystinemia and abdominal obesity on incidence of hypertension

SHANG Luxiang; YANG Bo; WANG Yue; HAN Meiling; MAN Shanshan; LIU Zhendong

doi:10.3969/j.issn.1002-266X.2016.33.004

Abstract：Objective To investigate the synergistic effect between hyperhomocystinemia (HHcy)and abdominal obe-sity on the incidence of hypertension.Methods Totally 3 591 subjects were enrolled from health care center.Participants were classified into two groups,namely,non-hypertension group (control group,n =1 235)and hypertension group (n =2 356).A questionnaire survey,physical examination and blood homocysteine (Hcy)test were carried out among the par-ticipants.Results After controlling the age,gender,smoking,alcohol consumption,physical activity and family hyper-tension history,Multiariable Logistic regression analysis showed that the risk of hypertension in patients with abdominal o-besity was 1.54 times higher than that of patients with normal waistline,and the risk of hypertension in patients with HHcy was 2.287 times higher than that of patients with normal Hcy (OR =2.287 and 1.54,all P <0.05).Interaction analysis showed that the risk of patients with HHcy and abdominal obesity was 3.464 times higher than that of patients without HHcy and abdominal obesity.The synergy index between hyperhomocystinemia and abdominal obesity on the incidence of hyper-tension was 1.253,the attributable proportion due to the interaction was 14.3% and the pure attributable proportion due to the interaction was 20.2%.Conclusion HHcy and abdominal obesity are risk factors for hypertension and there is a pos-itive synergistic effect between HHcy and abdominal obesity on the incidence of hypertension.