Expression of CADM1 and its clinical significance in human ovarian carcinoma
XIA Fen
HU Yanling
LI Li
Abstract：Objective To investigate the expression changes of cell adhesion molecule-1 (CADM1) in human ovari-an carcinoma and its clinical significance.Methods A total of 59 case of ovarian carcinoma tissues and matched tumor-adjacent tissues were collected.The mRNA and protein expression of CADM1 in the ovarian carcinoma tissues and matched tumor-adjacent tissues was examined by qRT-PCR, immunohistochemistry and Western blotting.The Chi-square test and Kaplan-Meier analysis was used to evaluate the correlation between CADM1 expression and clinicopathological characteris-tics or overall survival.Results The expression of CADM1 mRNA and protein in the ovarian carcinoma tissues was 0.28 ±0.12 and 1.32 ±0.23, respectively, 1.52 ±0.14 and 2.93 ±0.42 in the matched tumor-adjacent tissues, and signifi-cant difference was found between these two kinds of tissues (all P<0.05).The percentage of positive cells in the adja-cent tumor tissues (90%±5%) was significantly higher than that of the cancer tissues (10%±2%), P<0.05.The ex-pression of CADM1 was significantly associated with the FIGO stage, nodal metastasis and distant metastasis ( all P <0.05).The median survival time of patients with low expression of CADM1 (mRNA expression <0.57) was higher than that of patients with high expression (13.2 vs.24.5 months, P<0.05).Conclusion CADM1 is low expressed in the human ovarian cancer tissues.The low expression of CADM1 promotes the occurrence and development of ovarian cancer, and is related to its poor prognosis.
Keywords：ovarian carcinomacell adhesion molecule-1clinicopathological parameterprognosis
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 14-16 )