Efficacy of corticosteroids, cyclophosphamide and sildenafil on systemic lupus erythematosus combined with pulmonary arterial hypertension
WANG Zhiguo
LIU Xueming
TONG Shengquan
Abstract：Objective To investigate the clinical efficacy of corticosteroids, cyclophosphamide and sildenafil on sys-temic lupus erythematosus combined with pulmonary arterial hypertension ( SLE-PAH) .Methods Forty-six SLE-PAH pa-tients were selected and divided into two groups: the mild-to-moderate pulmonary artery systolic pressure ( PASP ) group (32 cases, PASP 30-70mmHg) and severe PASP group (14 cases, PASP>70 mmHg).Both groups were treated with prednisone, cyclophosphamide and sildenafil, lasting for 24 weeks.PASP, systemic lupus erythematosus disease activity index (SLEDAI), 6-minute walking distance and New York Heart Association (NYHA) classification of cardiac function were observed and evaluated.Results NYHA cardiac function improved in both groups after treatment (P<0.01).Both SLEDAI and PASP were decreased (P<0.05 or P<0.01) and 6-minute walking distance was increased (P<0.01). However, there was no statistical significance in the severe group between before and after treatment (P>0.05).After 24 weeks treatment, the efficacy rate in the mild-to-moderate PASP group was 87.5%, and 57.1%in the severe PASP group (P<0.05).No significant difference was found in the adverse reactions between these two groups (P>0.05).Conclu-sion Corticosteroids, cyclophosphamide and sildenafil have good efficacy on SLE-PAH, especially on those who suffer mild to moderate pulmonary arterial hypertension.
Keywords：systemic lupus erythematosuspulmonary arterial hypertensioncyclophosphamidecorticosteroidssil-denafil
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 42-44 )