Expression of SIRT1 in colorectal carcinoma and its relationship with and MDR-1
WANG Jing
CUI Min
ZHANG Qian
LI Hong
ZHANG Yan
CAO Zhang
Abstract：Objective To investigate the expression of silent information regulator 1 ( SIRT1) in colorectal carcinoma (CRC) and its relationship with and multidrug resistance-related protein 1 (MDR-1).Methods We used the imunohisto-chemistry method to detect the expression of SIRT 1 and MDR-1 and analyzed their relationships with clinical data in 162 specimens of CRC.Results SIRT1 and MDR-1 expression was detected in 107 (66.0%) and 96 (59.2%) out of 162 colorectal adenocarcinomas , respectively.Statistically, the expression of the SIRT1 protein was not associated with clinical and pathological parameters , including sex, tumor stage, lymph node metastasis and tumor differentiation (all P>0.05), but was associated with tumor size (P<0.05).In addition, the positive expression of SIRT1 and MDR-1 in CRC was posi-tively correlated with each other (r=0.506, P<0.01).Conclusion SIRT1 is highly expressed in the CRC and its ex-pression is positively correlated with MDR-1 expression.
Keywords：colorectal carcinomasilent information regulator 1multidrug resistance-related protein 1immunohisto-chemistry
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 17-19 )