Expression of ATP1A2 in gastric cancer and its mechanism
LI Zhi
WANG Shuo
HOU Kezuo
ZANG Dan
ZHENG Chunlei
CHE Xiaofang
QU Xiujuan
LIU Yunpeng
Abstract：Objective To observe the expression of ATP1A2 in gastric cancer tissues and to investigate the correla-tions of ATP1A2 expression with focal adhesion , cell adhesion molecules , calcium signaling and ECM receptor interaction pathways.Methods TCGA dataset which included 293 cases, and GEO dataset GSE62254 which included 300 cases, were collected.ATP1A2 expression was trisected into 3 levels: low, median, and high.The cutoff was set to 0.33 and 0.67.The relationships between ATP1A2 and clinicopathological characteristics as well as prognosis were assessed .GSEA was used to predict the functional gene sets modulated by ATP 1A2.Results There were 95 cases of low expression , 99 of median expression and 99 of high expression in TCGA dataset .The expression of ATP1A2 was significantly associated with T stage, lymph node metastasis, TNM stage and differentiation (all P<0.01), but was not associated with gender and age (all P>0.05).The median survival durations were 70, 36.9, and 26 months in low, median, and high ATP1A2 expres-sion subgroups, respectively.The P value was less than 0.05 in the log-ranked test.While in GSE 62254 dataset, there were 99 low expressed, 102 median expressed and 99 high expressed cases.Different expression of ATP1A2 was signifi-cantly associated with gender , age, T stage, N stage, pTNM stage and Lauren types (all P<0.05).The median survival duration in the high ATP1A2 subgroup was 31 months, while it was much longer in the median and low expression sub-groups (P<0.01).In GSEA, focal adhesion, cell adhesion molecules, calcium signaling, and extracellular matrix recep-tor interaction pathways were enriched in samples with high ATP 1A2 expression (P<0.05 or P<0.01).Conclusions ATP1A2 is highly expressed in gastric cancer tissues and the high expression indicates poor prognosis .The underlying mechanism might be that the high expression of ATP 1A2 causes the abnormity of focal adhesion , cell adhesion molecules , calcium signaling and extracellular matrix receptor interaction pathways .
Keywords：gastric carcinomacancer genome atlashuman cancer-related gene expression assemblyATP1A2
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 5-8 )