Effect of a KATP channel opener nicorandil on Warm-up phenomenon and HRR
ZHENG Mei
LI Lizhuo
JIANG Zhian
LI Lihong
LIANG Yun
LIU Jinbo
Abstract：Objective To investigate the effects of nicorandil which is a KATP channel opener on the warm-up phe-nomenon and the changes of heart rate recovery ( HRR) after sequential exercise test in patients with coronary artery disease. Methods Seventy-five patients with chronic stable angina who had positive exercise and were angiographically proved that the stenosis degree was 70-90% in at least one major branch were selected.They were divided into the control group with conventional treatment (25cases), nicorandil group which was treated by the conventional treatment +5 mg nicorandil, three times a day (25cases) and the isosorbide mononitrate group which was treated by the conventional treatment +20 mg isosor-bide mononitrate, twice a day (25cases).All of them underwent two cycles of exercise tests (EX1 and EX2) with interval of 15 min.We observed the ischaemic threshold values ( the corresponding heart-rate systolic blood pressure, RPP) , the time of reducing 0.1 mV ST-segment depression (T-STD), maximum STD (STD max), the recovery time to 0.05 mV ST-segment depression, whole exercise duration (ED) and the changes of HRR within and between the three groups.Results When we compared EX1 and EX2 among these three groups, each index of EX2 was improved as compared with that of EX1 ( P<0.05).Compared with the control group, only STDmax was improved better in the isosorbide mononitrate group (P<0.05). The changes of RPP, T-STD, the recovery time to 0.05 mV ST depression and STDmax in the nicorandil group were better than those of the control group and the isosorbide mononitrate group (P<0.05 or P<0.01).There was significant difference in HRR between EX1 and EX2 (P<0.01), as well as between the nicorandil group and the control group (P<0.05).Con-clusions Nicorandil promotes the occurrence of the warm-up phenomenon, and KATP channel may be as an important mech-anism involved in the warm-up phenomenon.Meanwhile, nicorandil is beneficial to HRR.
Keywords：coronary heart diseasenicorandilWarm-up phenomenonpotassium channelsexercise testheart rate recovery
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 5-8 )