Value of GDF-15, sST2 and BNP in evaluating cardiac function of patients with chronic heart failure

CUI Yuan; JIN Fengbiao; SUN Lixian; DING Zhenjiang; ZHANG Aiwen; JU Mingfei; ZHANG Na; SUN Hongchao; HOU Weina; HOU Ruitian

doi:10.3969/j.issn.1002-266X.2016.17.001

Abstract：Objective To investigate the value of growth differentiation factor 15 ( GDF-15 ) , soluble ST2 ( sST2 ) and brain natriuretic peptide (BNP) in evaluating the cardiac function of patients with chronic heart failure (HF).Meth-ods A total of 70 inpatients with chronic heart failure were divided into class Ⅲ(n=24) andⅣ(n=46) according to the NYHA class.Another 31 patients with hypertension or cardiac arrhythmias were recruited as the control group.Heart function, GDF-15, sST2 and BNP were detected by echocardiography, ELISA method and BNP bedside detector, respec-tively.Results Compared with control group, the levels of GDF-15, sST2, BNP, left ventricular end-diastolic dimension ( LVEDD) and left ventricular mass index ( LVMI) were higher, and the levels of left ventricular ejection fraction ( LVEF) and relative wall thickness ( RWT) were lower in the HF group, and the differences were statistically significant ( all P<0.01).Compared with NYHAⅢHF patients, the levels of GDF-15, sST2, BNP, LVEDD and LVMI were higher, the levels of LVEF and RWT were lower in NYHA Ⅳ HF patients, and the differences were statistically significant ( all P<0.05).Spearman correlation analysis showed that sST2, GDF-15 and BNP were positively correlated with LVMI and NY-HA class (r=0.351, 0.236, 0.449;0.339, 0.305, 0.579;all P<0.05), while were negatively correlated with RWT and LVEF (r=-0.380,-0.255,-0.496; -0.257,-0.298, -0.409;all P<0.05).GDF-15 and sST2 were posi-tively correlated with BNP (r=0.289, 0.300; all P<0.05).ROC curve analysis showed that the area under curve of NYHA Ⅲand NYHAⅣwith BNP, GDF-15 and sST2 were 0.852, 0.678 and 0.706, respectively (all P<0.05).Con-clusion The levels of GDF-15, sST2 and BNP are closely related with cardiac functional status in patients with chronic HF, and they all may reflect the severity of the patients′condition, but BNP has a higher sensitivity and specificity in the evaluation of cardiac function in HF patients.