Risk factors for aspirin resistance in patients with acute cerebral infarction

ZHANG Shijuan; SONG Yuning; LI Naikun; SUN Xipo; LI Bingxuan

doi:10.3969/j.issn.1002-266X.2016.15.022

Abstract：Objective To investigate the risk factors for aspirin resistance ( AR) in patients with acute cerebral in-farction. Methods Totally 162 cases of patients with acute cerebral infarction received aspirin enteric-coated tablets 100 mg/d at the beginning of the day of admission. After taking aspirin 10 d, all patients were divided into the AR group (49 cases) and non-AR group (113 cases) according to the results of platelet aggregation test. The clinical data of patients were collected. The expression of microRNA-19a (miR-19a) in the platelets was detected by real-time fluorescence quanti-tative PCR. The influencing factors for the occurrence of AR were analyzed by Logistic regression analysis. The predictive value of expression of miR-19a in platelet for AR was analyzed by using receiver operating characteristic curve ( ROC curve). Results The expression level of miR-19a in the AR group was 0. 78 ± 0. 09, the type 2 diabetes were found in 26 cases (53. 1%), while in the non-AR group, the expression level of miR-19a was 0. 59 ± 0. 11, the type 2 diabetes were found in 34 cases (30. 1%), and significant difference was found between the two groups, all P<0. 05. Multivariate Lo-gistic regression analysis showed that the increased expression of miR-19a in platelet was an independent risk factor for AR in patients with acute cerebral infarction (OR=4. 82, 95% CI:1. 374-15. 835). ROC curve analysis showed that, when miR-19a cutoff value was 0. 69, the area under the ROC curve was 0. 927 (95% CI:0. 888-0. 966), the sensitivity was 93. 9% and the specificity was 82. 3%. Conclusion The expression of miR-19a in platelet of AR in patients with acute cerebral infarction is increased, which is an independent risk factor for the occurrence of AR and may be used as an indica-tor to predict the occurrence of AR in acute cerebral infarction.