Effects and mechanism of tea polyphenol on proliferation and apoptosis of human laryngeal cancer Hep-2 cells
TIAN Mengqiu
LIU Jian
ZHENG Jiafa
Abstract：Objective To observe the effects of tea polyphenol ( TP) on the proliferation and apoptosis of human la-ryngeal cancer Hep-2 cells, and to investigate its mechanism. Methods The Hep-2 cells were cultivated, and were treated with different concentrations of TP. The proliferation inhibition rate and the nuclear shape of Hep-2 cells were compared, and the relative expression of Caspase-3, Bax and Bcl-2 mRNA in cells was compared. Results TP inhibited the prolifera-tion, induced apoptosis of Hep-2 cells, up-regualted the expression of Caspase-3 and Bax mRNA, and down-regulated the expression of Bcl-2 mRNA, which was in a dose-dependent manner. (all P<0. 05). Conclusions TP can inhibit the proliferation of Hep-2 cells, and induce its apoptosis. The mechanism may be related to the up-regulated expression of Caspase-3 and Bax mRNA and down-regulated expression of Bcl-2 mRNA.
Keywords：tea polyphenollaryngeal carcinomaCaspase-3 proteinBax proteinBcl-2 protein
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 27-29 )