Expression and significance of CD69 and HLA-DR in T lymphocytes of peripheral blood in perioperative period of patients with colorectal cancer
WANG Xiangan
WU Qiong
YU Liming
ZOU Zhenhong
CAI Lei
XIONG Ni
YANG Gang
Abstract：Objective To observe the expression changes and significance of CD69 and HLA-DR in T lymphocytes of peripheral blood in perioperative period of patients with colorectal cancer.Methods Flow eytometry was used to detect the expression of CD69 and HLA-DR in T lymphocytes of peripheral blood in 40 cases of perioperative period ( including the preoperative and postoperative 5, 10 days) of patients with colorectal cancer (observation group), and in 15 cases of healthy persons ( control group) .The relationship of their expression with clinicopathologic features was analyzed.Results The expression of CD69 and HLA-DR before surgery was significantly lower in the observation group than that of the con-trol group (P<0.05), with further increase after surgery (P<0.05).The expression of HLA-DR was related with lymph node metastasis, distant metastasis and TNM stage after surgery (P<0.05), but was not related with the rest of clinico-pathologic features (all P>0.05).Conclusions The expression of CD69 and HLA-DR before surgery in T lymphocytes of peripheral blood in the perioperative period of patients with colorectal cancer was significantly decreased, and gradually in-creased after surgery.The detection of CD69 and HLA-DR contributes to determining the state of an illness and guiding im-mune therapy for colorectal cancer.
Keywords：colorectal carcinomaperioperative periodT lymphocytesCD69HLA-DR
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 7-9 )