Expression and clinical significance of DEC1/DEC2 mRNA in non-small-cell lung cancer
MA Yuhua
PENG Haiying
WANG Zhihui
GAO Wei
WANG Yunshan
Abstract：Objective To investigate the effects of differentiated embryo-chondrocyte expressed gene 1 (DEC1) and DEC2 mRNA in the occurrence and development of non-small-cell lung cancer (NSCLC).Methods Forty-two cases of cancer tissue samples and 28 cases of adjacent normal tissues were collected from NSCLC patients.The relative expression levels of DEC1 and DEC2 mRNA were detected by real-time RT-PCR.The relationships between DEC1 and DEC2 mRNA and the clinicopathological characters of NSCLC patients were discussed.Results The relative expression of DEC1 mRNA was 0.0456 in the cancer tissues and 0.0017 in the normal tissues, the relative expression of DEC2 mRNA in the cancer tissues and normal tissues was respectively 0.0566 and 0.0009, and significant difference was found between these two groups ( all P＜0.05) .The expression of DEC1 and DEC2 mRNA in the NSCLC tissues was not related with gender, age, tumor diameter, differentiated degree and TNM stage (all P＞0.05).DEC1 and DEC2 mRNA was expressed higher in the adenocarcinoma than that in squamous carcinoma (all P＜0.05).DEC1 mRNA was positively correlated with DEC2 mR-NA (γ=0.691, P＜0.05).Conclusion DEC1 and DEC2 is over expressed in NSCLC tissues and its expression changes may be involved in the occurrence and development of NSCLC.
Keywords：non-small-cell lung cancerdifferentiated embryo-chondrocyte expressed gene 1differentiated embryo-chondrocyte expressed gene 2relative quantitative real-time RT-PCR
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 20-23 )