Plasma levels of miR-10b, miR-122, miR-16 and miR-183 in patients with non-small-cell lung cancer and their relationships with the overall survival
WANG Fumin
ZHANG Huan
QU Jinli
QIAN Biyun
Abstract：Objective To observe the levels of miR-10b, miR-122, miR-16 and miR-183 in patients with non-small-cell lung cancer (NSCLC) and to explore their relationships with the overall survival .Methods According to recurrence, 40 NSCLC patients were divided into two groups:non-recurrence group (n=8) and recurrence group (n=32).The ex-pression levels of 4 miRNAs were detected by real time quantitative PCR .NSCLC patients were divided into the high miR-NA expression group and low expression group according to the mean value of miRNAs expression .Kaplan-Meier survival a-nalysis and Cox regression were performed to determine the associations between different levels of miRNAs expression and overall survival ( OS) .Results The expression of miR-183 was higher in the non-recurrence group as compared with that of the recurrence group (P<0.05).The OS of patients with low miR-183 expression level was higher than that with high miR-183 expression (P<0.05), and there was no significant difference in the OS of patients with different miRNA expres -sion levels (all P>0.05).Cox proportional hazard regression showed that miR-183 was the independent risk factor for the overall survival of NSCLC patients (HR=2.854, 95%CI=1.154-7.055, P<0.05).Conclusion The plasma level of miR-183 in patients with NSCLC is related to the overall survival , but plasma levels of miR-10b, miR-122 and miR-16 are not associated with the overall survival of patients.
Keywords：non-small-cell lung cancermicroRNAoverall survival
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 17-19,后插1 )