Predictive value of non-invasive serum models in assessment of esophageal varices in patients with alcoholic liver cirrhosis

WANG Xiaotong; HAN Tao; LI Yayue

doi:10.3969/j.issn.1002-266X.2016.08.002

Abstract：Objective To investigate the predictive value of red cell volume distribution width ( RDW) to platelet ratio (RPR),γ-glutamyltransferase to platelet ratio index (GPRI), S-index, fibrosis index based on the 4 factor (FIB-4) and as-partate aminotransferase ( AST) to platelet ratio index ( APRI) in the non-invasive serum models in assessing esophageal vari-ces in patients with alcoholic liver cirrhosis .Methods Totally 126 patients with alcoholic liver cirrhosis including 20 cases of patients complicated with mild and moderate esophageal varices ( mild and moderate group ) , 67 cases of severe esophageal varices (severe group) and 39 cases of non-esophageal varices (non-varices group) were enrolled.Blood routine (RDW and PLT) and liver function (ALT, AST, GGT and ALB) were tested, and RPR, GPRI, S-index, FIB-4, APRI were calculat-ed.Receiver operating characteristic (ROC) curves and the areas under the curves (AUCs) were calculated to assess the performance of these models in predicting esophageal varices .Results RPR, GPRI, S-index, FIB-4 and APRI in the severe group were higher than those of the mild and moderate group and non-varices group (all P<0.05);and no significant differ-ences were found in the above indexes between the mild and moderate group and non-varices group (all P>0.05).The AUCs of RPR, GPRI, S index and FIB-4 in predicting esophageal varices were respectively 0.902, 0.828, 0.960, 0.883 and 0.799; AUCs of RPR, GPRI, S index and FIB-4 in predicting severe esophageal varices were respectively 0.891, 0.782, 0.836, 0.816 and 0.762.Conclusion RPR, GPRI, S-index, FIB-4 and APRI in the non-invasive serum models are of clinical value in assessing the presence and severe degrees of esophageal varices in patients with alcoholic liver cirrhosis and can be used as the non-invasive assessment methods.