Stability of esomeprazole sodium for injection in different solvents and different drug compatibility
ZHANG Xuening
ZHANG Limin
GAO Yaling
WANG Gang
KANG Zekun
XU Meng
Abstract：Objective To observe the stability of esomeprazole sodium fro injection in different solvent and different drug compatibility.Methods Forty mg esomeprazole sodium for injection was respectively dissolved in 100 mL of 0.9%sodium chloride, xylitol, 10%glucose, 5%glucose, 5%fructose and glucose and sodium chloride injection.The concen-trations of esomeprazole sodium in different solvents at 0, 0.5 h, 1 h, 2 h, 3 h, 4 h, 6 h, 8 h and 12 h were detected by HPLC, and we also observed the changes in appearance and measured pH value.The best solvent with stable drug compati-bility was used to mix with esomeprazole sodium solution.The esomeprazole sodium solution of 100 mL was repsectively mixed with 10 mL vitamin C, levofloxacin lactate, compound amino acid, vitamin B6, hydrochloric acid methoxy metoclo-pramide, ondansetron hydrochloride our Joan, glucose acid calcium, Tanreqing injection Reduning injection and mannitol injection.The color change of compatibility was observed at 0, 0.5 h, 1 h, 2 h, 3 h, 4 h, 6 h, 8 h and 12 h .Results When the esomeprazole sodium for injection was dissolved in 0.9%sodium chloride and xylitol within 12 h, the PH val-ue and drug concentration were in a stable state;when dissolved in other solutions within 12 h, the PH value and drug con-centration were decreased.The 0.9% sodium chloride injection was selected as esomeprazole sodium solvent, When we mixed esomeprazole sodium with vitamin C, the color changed after 8 h;when we mixed esomeprazole sodium with levoflox-acin lactate, compound amino acid, vitamin B6, hydrochloric acid methoxy metoclopramide, ondansetron hydrochloride our Joan and gluconic acid, the color changed after 6 h;and when we mixed esomeprazole sodium with Tanreqing injection and Reduning injection, the color changed after 4 h and when we mixed with mannitol injection, the color changed after 1 h. Conclusion The PH value and drug concentration were in a stable state when the esomeprazole sodium for injection was dissolved in 0.9%sodium chloride, and the color changed in a short time when the esomeprazole sodium was compatible with Tanreqing injection, Reduning injection and mannitol injection, thus the clinical medication should be paid attention to.
Keywords：esomeprazole sodiumesomeprazole sodium for injectionsolventdrug compatibility
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 24-26 )