Changes in morphology of chorion tissue and expression of estrogen receptor and progesterone receptor in early pregnant women at different time points after taking mifepristone
HAN Hua
ZHAO Hongwei
LI Jie
YAN Ping
Abstract：Objective To observe the changes in morphology of chorion tissue and expression of estrogen receptor ( ER) and progesterone receptor ( PR) in early pregnant women at different time points after taking mifepristone.Methods Eighty women who desire to terminate the early pregnancy were randomly divided into the control group, 12-hour group, 24-hour group and 48-hour group, and each group contained 20 cases.Women in the 12-hour group, 24-hour group and 48-hour group took 150 mg mifepristone.Negative pressure suction were performed after 12, 24 and 48 hours respectively in the three groups.The chorion tissue were collected after suction.We observe the morphological change of chorion tissue by light microscope and transmission electron microscope.Detecting the expression of ER and PR in the chorion tissue by immunohistochemistry.Results Three medication groups showed the cell degenerated, some were necrotic, even fell off, the inflammatory cell infiltrated, the chorion interstitial had edema and the ultrastructure was damaged.The relative expres-sion levels of ER in the control group, 12-hour group, 24-hour group and 48-hour group were 0.182 4 ±0.007 2, 0.119 1 ±0.005 9, 0.120 8 ±0.011 0 and 0.121 2 ±0.007 3.The relative expression levels of PR were 0.179 0 ±0.008 2, 0.132 7 ±0.007 0, 0.128 5 ±0.006 5 and 0.126 2 ±0.010 9.Significant differences were found in the ER and PR be-tween the three medication groups and control group (all P<0.05).Conclusion The chorion tissue degenerates and shows necrosis and the expression of ER and PR is inhibited after taking mifepristone twelve hours.
Keywords：mifepristoneestrogen receptorprogesterone receptorchorion tissues
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 7-9 )