Expression changes of AKT1 and PDCD4 in non-small-cell lung cancer tissues and the significance
WANG Jia
LYU Yanchao
XU Haoran
HAN Shuangshuang
ZHU Zhenlong
Abstract：Objective To observe the expression changes of AKT1 and programmed cell death receptor 4 ( PDCD4 ) in tissues of non-small-cell lung cancer ( NSCLC) and to investigate its clinical significance.Methods We selected 65 cases of NSCLC tissues ( NSCLC group) , 30 cases of normal alveolar tissues ( alveolar group) and 30 cases of bronchial stump tissues ( bronchial group) .The expression of AKT1 and PDCD4 in the three groups was detected by immunohisto-chemistry, and we analyzed its relationship with the clinical and pathological data in the NSCLC group.Results Com-pared with the alveolar group and bronchial group, the expression of AKT1 was increased while the expression of PDCD4 was decreased in the NSCLC group (all P<0.05).In the NSCLC group, the expression of AKT1 was related with tumor differentiation, lymph node metastasis and TNM staging (all P<0.05), but was not related with gender, age, tumor size and histological type;the expression of PDCD4 was related with tumor histological type (P<0.05), but was not related with gender, age, tumor size, differentiation, lymph node metastasis and TNM staging.The expression of AKT1 and PD-CD4 in the lung adenocarcinoma tissues was negatively correlated (r=-0.436, P=0.021), but was not related with each other in the lung squamous-cell carcinoma tissues (r=-0.012, P=0.931).Conclusion The expression of AKT1 was increased and PDCD4 was decreased in NSCLC tissues, and the combined detection of them contributed to the diagno-sis, treatment and prognosis of NSCLC.
Keywords：non-small-cell lung cancerpulmonary alveolibronchiserine-threonine protein kinaseprogrammed cell death receptor 4
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 16-18 )