Effects of carboplatin combined with paclitaxel in neoadjuvant chemotherapy on cardiac function of patients with esophageal cancer
WANG Tingfeng
LYU Jin
ZHOU Guozhi
Abstract：Objective To evaluate the effects of carboplatin combined with paclitaxel during neoadjuvant chemothera-py on cardiac function of patients with esophageal cancer.Methods Totally 46 patients with esophageal cancer received the neoadjuvant chemotherapy with carboplatin and paclitaxel for 5 weeks before the operation.We recorded the heart rate, measured the systolic blood pressure and diastolic blood pressure, detected the blood creatine kinase, creatine kinase isoenzyme, brain natriuretic peptide and troponin, and examined the left ventricular end-systolic volume, left ventricular end-diastolic volume, left ventricular ejection fraction, ventricular volume and blood flow velocity of inferior vena cava be-fore and after chemotherapy.Univariate Logistic regression analysis was conducted on the index changes after chemothera-py, and the change value and 95%confidence interval (95%CI) were calculated.Results After 46 patients with esopha-geal cancer received the neoadjuvant chemotherapy with carboplatin and paclitaxel for 5 weeks, the systolic blood pressure dropped an average of 18 mmHg, 95%CI (25, -10), P<0.05;diastolic blood pressure dropped an average of 6 mmHg, 95%CI (-14, -2), P<0.05;the heart rate increased an average of 5/min, 95%CI(1, 11), P<0.05;troponin in-creased an average of 0.008 mmol/L, 95%CI(-0.002, -0.012), P<0.05;creatine kinase increased an average of 42 IU/L, 95%CI(18, 71), P<0.05; and ventricular volume dropped an average of 54 mL, 95%CI( -72, -39), P<0.05.No significant differences were found in the rest of indexes before and after surgery.Conclusion The myocardial creatine kinase increased, systolic blood pressure and diastolic blood pressure decreased and the ventricular size became smaller in patients with esophageal cancer receiving neoadjuvant chemotherapy of carboplatin and paclitaxel.
Keywords：esophageal carcinomacarboplatinpaclitaxelneoadjuvant chemotherapyheart function
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 7-9 )