Expression changes of Wnt2 and Dvl mRNA and protein in esophageal squamous-cell carcinoma and the significance
WANG Yongtao
WANG Yang
SHANG Ziqiang
WANG Hongjiang
Abstract：Objective To observe the expression changes of Wnt2 and dishevelled ( Dvl) mRNA and protein in the esophageal squamous-cell carcinoma ( ESCC) tissues, and to investigate the significance.Methods Sixty cases of tumor tissue specimens ( observation group) and adjacent tissues ( control group) from ESCC patients were selected.The mRNA and protein expression of Wnt2 and Dvl in the two groups was respectively detected by RT-PCR and Western blotting.Re-sults In the observation group, the mRNA expression of Wnt2 and Dvl was respectively 1.007 ±0.237 and 1.008 ± 0.220, the protein expression of Wnt2 and Dvl was respectively 0.512 ±0.406 and 1.218 ±1.082, and that in the control group was respectively 0.877 ±0.119, 0.891 ±0.196, 0.153 ±0.189 and 0.505 ±0.358.The mRNA and protein ex-pression of Wnt2 and Dvl in the observation group was higher than that of the control group ( all P<0.05) .In the observa-tion group, Wnt2 and Dvl mRNA was positively correlated with each other (r=0.807, P<0.01).Conclusion The high expression of Wnt2 and Dvl gene is found in ESCC tissues, which indicates Wnt signaling pathway plays an important role in the occurrence and development of ESCC.
Keywords：esophageal carcinomasquamous-cell carcinomaWnt signaling pathwaywnt proteindishevelled pro-tein
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 4-6 )