Changes in levels of serum visfatin and the relationships with activator protein-1 and MMP-2 in patients with angina pectoris
WANG Ting
XIA Dasheng
HE Qiang
YE Xuying
LIANG Jingyi
WANG Li
Abstract：Objective To investigate the relationships between serum visfatin and activator protein-1 (AP-1), matrix metalloproteinase 2 ( MMP-2 ) in patients with angina pectoris.Methods The serum visfatin, phosphorylated c-Jun, MMP-2 and TIMP-2 were detected in 75 cases of patients with unstable angina pectoris ( UAP group) , 65 cases of stable angina pectoris ( SAP group) and 60 cases of healthy controls ( control group) by using ELISA.Results The serum levels of visfatin, phosphorylated c-Jun, MMP-2, TIMP-2 and the ratio of MMP-2/TIMP-2 in the UAP group were significantly higher than those in the SAP group (all P<0.01).All the parameters mentioned above were higher in the SAP group than those of the control group (all P<0.01).Pearson correlation analysis showed that the serum visfatin level was positively correlated with phosphorylated c-Jun, MMP-2, TIMP-2 and MMP-2/TIMP-2 ( r=0.662, 0.657, 0.456 and 0.273, re-spectively;all P<0.01) , while phosphorylated c-Jun was positively correlated with MMP-2, TIMP-2 and MMP-2/TIMP-2 (r=0.588, 0.433 and 0.184, respectively;all P<0.05).Conclusion The serum levels of visfatin in patients with an-gina pectoris are significantly increased, and it may lead to the unstability of atherosclerotic plaque through the regulation of MMP-2′s secretion by activating AP-1.
Keywords：angina pectorisvisfatinactivator protein-1matrix metalloproteinase 2
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1-3 )