Effect of losartan on aortic stiffness in hemodialysis patients
SUN Fang
LIU Jing
SHEN Yang
MA Lijie
HUANG Jing
CHEN Xiangdong
ZHAO Sumei
ZHOU Yilun
Abstract：Objective To investigate the effect of the angiotensin Ⅱ receptor blocker losartan on arterial stiffness in hemodialysis patents and its mechanism. Methods Seventy-two hemodialysis patients were randomly assigned to receive either 50 mg losartan, qd (n=36, losartan group) or 5 mg β-blocker bisoprolol, qd (n=36, bisoprolol group). The home blood pressure ( Home-BP ) , aortic pulse wave velocity ( PWV ) , common carotid artery intima-media thickness (IMT), intima-media cross sectional area (IMCSA), serum oxidized low density lipoprotein (ox-LDL) and homeostasis model assessment index of insulin resistance ( HOMA-IR) were determined before treatment and 12 months after treatment. Results After treatment, no significant difference was found in Home-BP between the two groups (P>0. 05). Compared with that before treatment, PWV was decreased in both groups, and the reduction was more significant in the losartan group than that in the bisoprolol group (all P<0. 05). No change in IMT was observed (P>0. 05), and IMCSA was significant-ly decreased in the losartan group after treatment (P<0. 01). On the contrary, no change was found in IMCSA (P>0. 05), but IMT was significantly increased in the bisoprolol group (P<0. 01). In the losartan group, serum ox-LDL and HOMA-IR were significantly decreased (all P<0. 01), but they had no significant change in the bisoprolol group (all P>0. 05). Conclusions Arterial stiffness was significantly attenuated by treatment with losartan in hemodialysis patients, and the effect might be independent of blood pressure reduction, but related to decreasing oxidative stress, improving insu-lin resistance and reducing artery hypertrophy.
Keywords：hemodialysisarterial stiffnesslosartan
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )