Expression changes of Cbl-b and Itch in breast carcinoma and the clinical significance
Han Mingqiang
LI Jianhui
YAN Jingbo
LIU Chengxiang
CUI Zhanbin
Abstract：Objective To investigate the expression changes of Cbl-b and Itch in the breast carcinoma tissues and the clinical significance.Methods The expression of Cbl-b and Itch in 116 specimens of breast carcinoma and 30 specimens of normal breast tissues was detected by immunohistochemistry.Meanwhile, we also statistically analyzed its relationship with the clinical and pathological factors.Results The positive expression rates of Cbl-b and Itch in the breast carcinoma tissues were respectively 78.45%(91/116) and 58.62%(68/116).The positive expression rates of Cbl-b and Itch in the normal tisseus were 26.67%(8/30) and 23.33%(7/30).The positive expression rates of Cbl-b and Itch in the breast cancer tissues were higher than those of the normal tissues (all P<0.01).The positive expression of Cbl-b and Itch was positively correlated with depth of invasion, lymph node metastasis and TNM staging (r=0.172,P=0.014;r=0.119, P=0.022;r=0.117,P=0.017;r=0.145,P=0.028; r=0.134,P=0.027; r=0.138,P=0.025).The positive ex-pression of Cbl-b and Itch was not related with age of patient and the lesion size (all P>0.05).Conclusion The expres-sion of Cbl-b and Itch is increased in the breast cancer tissues, and both of them take part in the progress of breast carcino-ma.
Keywords：breast neoplasmsCbl-b proteinItch protein
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 15-17 )