Expression changes and significance of ERG protein in prostate cancer
JING Zhiliang
CHEN Yonghua
CAO Jun
ZHAO Yinghai
LIU Jianjun
Abstract：Objective To investigate the expression changes and significance of ERG protein in the prostate cancer ( PCa) tissues.Methods The prostate tissues from 144 patients with PCa and 100 patients with benign prostatic hyperpla-sia ( BPH) were selected.The expression of ERG protein was detected by immunohistochemical MaxVision method, and their relationships with clinicopathological parameters were analyzed.Results The positive expression rates of ERG pro-tein in the PCa and BPH tissues were 25.0%and 0, respectively (P<0.01).The ERG protein expression in the PCa tis-sues was not related with age of patient, preoperative PSA value and distant metastasis (all P>0.05), and was negatively correlated with Gleason score (r=-0.175, P<0.05).The ERG protein expression rate in the Gleason score≤7 group was significantly higher than that of the Gleason score >7 group (P<0.05).Conclusion The expression of ERG pro-tein in the prostate cancer tissues of PCa patients is increased, and the ERG protein detection may provide a reference for the differential diagnosis and pathological grading.
Keywords：prostatic neoplasmsERG proteinprostatic hyperplasiaGleason score
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 12-14 )