Evaluation of different indices of insulin resistance in overweight and obese population
YU Yun-cui
ZHU Rong
XIA Li-li
LIU Fen
HE Yan
Abstract：Objective To observe the accuracy of several indices in assessing insulin resistance ( IR ) in the over-weight/obesity population and to find more desirable cut-off point of IR .Methods This study involved 406 overweight/o-besity participants without overt diabetes .Homeostasis model assessment of insulin resistance (HOMA-IR) index, Quanti-tative insulin sensitivity check index (QUICKI) and McAuley index (McA index) were calculated and compared with fast-ing insulin levels ( FINS) (≥12 mIU/L, which was the reference criteria for determined IR ) .Results Of the 406 partic-ipants, 114 cases of IR and 292 cases of non-IR were found.When using HOMA-IR≥2.6 as the cut-off point of IR, there were 138 cases of IR and 268 cases of non-IR.The sensitivity was 94.74%and the specificity was 89.73%.Youden index was 0.84.When using HOMA-IR≥2.68 as the cut-off point, the sensitivity and specificity was 93.3%and 92.9%, re-spectively.Youden index was elevated to 0.86.When using QUICKI≤0.339 as the cut-off point of IR, there were 210 ca-ses of IR and 196 cases of non-IR.The sensitivity was 100%and the specificity was 67.12%.Youden index was 0.67. When using QUICKI≤0.335 as the cut-off point, the sensitivity and specificity was 79.8% and 99.0%, respectively. Youden index was increased to 0.79.When using McA≤5.8 as the cut-off point of IR, there were 403 cases of IR and 3 cases of non-IR.The sensitivity was 98.25%and the specificity was only 0.34%.Youden index was -1.41.When using McA≤4.29 as the cut-off point, the sensitivity and specificity was 78.0% and 82.9%, respectively.Youden index was increased to 0.61.Conclusions HOMA-IR is more accurate in detecting IR in overweight/obese population.The thresh-olds of these three indices in overweight/obese population should be adjusted appropriately considering the influence of obe -sity and lipid metabolism on insulin levels to increase the accuracy in evaluating IR .
Keywords：overweightobesityinsulin resistanceinsulin resistance indexhomeostasis model assessment of insu-lin resistance indexquantitative insulin sensitivity check indexMcAuley index
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 14-16 )