Expression changes of NF-κBp65 in hepatocellular carcinoma tissues and its clinical significance
CHEN Zeng-yin
ZHAO Ye-min
SHANG He-zhen
SHI Guang-jun
Abstract：Objective To detect the expression changes of nuclear transcription factor ( NF)-κBp65 in the hepatocel-lular carcinoma ( HCC) tissues and to explore its clinical significance .Methods The expression of NF-κBp65 protein was detected by immunohistochemistry in the resected HCC tissues , adjacent tissues and normal liver tissues through sur-gery.Results The positive expression rates of NF-κBp65 protein in the HCC tissues, adjacent tissues and normal tissues were 60.67%, 22.67%and 12.00%, respectively.There were significant differences between each two groups (all P<0.05).The positive rates of NF-κBp65 in HCC tissues with positive or negative HBsAg were 64.44%and 26.67%, and the difference was statistically significant (P<0.05).The positive expression of NF-κBp65 protein was related with patho-logical grade and lymph node metastasis (all P<0.05).The survival time distribution of NF-κBp65 negative group was better than that of the NF-κBp65 positive group, but the difference was not significant (P>0.05).Conclusions The ex-pression of NF-κBp65 was increased significantly in the carcinoma tissues of HCC patients , and the positive expression rate is high in HBV positive cancer tissues .NF-κBp65 may be involved in the occurrence and development of liver cancer .
Keywords：liver neoplasmsliver carcinomanuclear transcription factor-κBp65
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 8-10 )