Effects of low-level carotid baroreceptor stimulation on isoproterenol-induced ventricular arrhythmias
LIAO Kai
LI Qi-dong
FANG Shi-hu
ZHANG Li
YU Li-lei
JIANG Hong
Abstract：Objective To investigate the effects of low-level carotid baroreceptor stimulation ( LL-CBS) on isoproter-enol-induced ventricular arrhythmias ( VAs) .Methods Twenty adult mongrel dogs were randomly divided into the LL-CBS group (n=10) and the control group (n=10).The stimulating electrode of carotid artery was placed to monitor the blood pressure ( BP) and heart rate ( HR) .After 1 hour of LL-CBS the VAs was induced by isoproterenol in the LL-CBS group.The stimulation was not stopped until the experiment was over .The false LL-CBS was given to the dogs in the con-trol group.The ventricular effective refractory period ( ERP) during baseline and 1 hour.Each dog underwent three in-duction episodes.The occurrence time of first arrhythmic beat, the number of ventricular premature beat, the number and the duration of ventricular tachycardia were measured and analyzed .Results The values of BP and HR were not signifi-cantly different between the two groups during baseline , 1 hour and intravenous isoproterenol ( all P>0 .05 ) .The ERP was (165 ±5) ms in the LL-CBS group and (168 ±8) ms in the control group during baseline (P>0.05), and the ERP was respectively (181 ±7) ms and (162 ±7) ms in the LL-CBS group and control group 1 hour after stimulation (P<0.05).The occurrence of VAs in the LL-CBS group was less than that in the control group every time (all P<0.05).The occurrence time of first ventricular premature beat of the LL-CBS group was 341 (512, 224) s, and 215 (327, 90) s in the control group;the number of premature ventricular contractions was 52 (83, 20), and 107 (162, 54) in the control group;and the number of ventricular tachycardia was 2.3 (6.7, 0.5), and 5.5 (9.3, 2.4) in the control group (all P<0.05).Conclusion LL-CBS inhibits the occurrence of isoproterenol-induced VAs without chan-ges of BP and HR .
Keywords：ventricular arrhythmiaslow-level carotid baroreceptor stimulationisoproterenolcanine
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 21-24 )