Relationship between curative effect of neoadjuvant chemoradiotherapy on rectal cancer and XPG C46T gene polymorphisms in rectal cancer tissues
HUANG Wen-yu
TANG Fan
SUN Sheng
CAO Chuan-pei
WANG Bin
Abstract：Objective To investigate the effect of XPG C46T gene polymorphisms in rectal cancer tissues on neoadju-vant chemoradiotherapy .Methods Forty-five patients with low rectal cancer (Ⅱ-Ⅲmidterm) were given XELOX chemo-therapy ( oxaliplatin combined with capecitabine ) before surgery .CT or MRI examination was conducted to evaluate the ef-ficacy after radiotherapy 6-8 weeks.The XPG C46T genotype was detected before and after radiotherapy by RT-PCR.Re-sults After neoadjuvant chemoradiotherapy , 27 cases were effective , 18 cases were non-effective, and the effective rate was 60.00%.The efficacy of neoadjuvant chemoradiation was not related with gender , age, pathological type and KPS score of colorectal cancer patients (all P>0.05).There were 18 cases of XPG C46T genotype C/C in the rectal cancer tis-sues of patients with effective neoadjuvant chemoradiotherapy , 3 cases in patients with non-effective neoadjuvant chemora-diotherapy (P<0.05);there were respectively 6 cases of C/T and 9 cases in patients with effective and in patients with non-effective neoadjuvant chemoradiotherapy (P<0.05);T/T were respectively 3 cases and 6 cases in patients with effec-tive and in patients with non-effective neoadjuvant chemoradiotherapy (P<0.05).Conclusions The XPG C46T gene C/C genotype ratio in patients with effective neoadjuvant chemoradiotherapy is higher , C/T and T/T genotype ratios are lower than those of the invalid ones .The detection of XPG C46T gene polymorphism can be used to predict the curative effect of colorectal cancer in Ⅱ-Ⅲstage.
Keywords：rectal carcinomagene polymorphismneoadjuvant chemoradiotherapyXPG C46T geneXELOX chem-otherapy
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 8-10 )