HPV genotyping detection of HPV positive women with negative cervical cytology

ZHANG Shan; HONG Ying; MA Li; LAN Ming

doi:10.3969/j.issn.1002-266X.2015.43.002

Abstract：Objective To investigate the clinical significance of HPV genotyping detection in patients with negative cervi-cal cytology and positive human papilloma virus (HPV). Methods A total of 200 women with negative cervical cytology and positive HPV received the HPV genotyping detection and were referred to colposcopy and histopathological examination. The cor-relation between different HPV subtype infection and cervical intraepithelial neoplasia(CINⅡ) + was analyzed. The women whose pathological diagnosis were CINⅠand cervicitis were followed up for one year by the method of TCT and HPV genotyping detec-tion. Results Of 200 women, 37 patients were CINⅡ+(18. 6%). The risk of patients with HPV16 infection to develop CINⅡ+was 2. 608 times higher than that of patients without HPV16 infection (OR=2. 608, P<0. 05). Of 151 patients with CINⅠand cervicitis who finished the follow-up, the prevalence of cervical intraepithelial neoplasia in patient with homotype HPV infection was higher than that in patients with heterotype HPV infection (P<0. 01). And the risk of higher pathological progression in pa-tients with homotype infection was 14. 89 times higher than that in patients with heterotype HPV infection. Conclusions HPV genotyping detection has important clinical significance for cervical cytology negative and HPV positive women. It is recommend that cervical cytology negative and HPV16 positive women should be referred to colposcopy immediately. HPV genotyping detec-tion can be used for the follow-up of cervical cytology negative and HPV positive women, and patients with positive homotype HPV infection should be referred to colposcopy, especially those with HPV16 infection.