Effect of ulinastatin and tranexamic acid on inflammatory and coagulation indexes in children undergoing ventricular septal defect repair
LIU Yan-qin
LI Su-ling
ZHAO Hai-tao
ZHAO Yan-li
GAO Yi
YANG Yong-hui
Abstract：Objective To explore the effect of ulinastatin and tranexamic acid on inflammatory and coagulation indexes in children undergoing ventricular septal defect repair .Methods A total of 200 children diagnosed with ventricular septal defect were divided into four groups, 50 cases in each group: ulinastatin group (group A), tranexamic acid group (group B) , combination group ( group C) and the control group .The volume of drainage from pericardium and frozen plasma infusion volume during the operation were recorded .We took the blood from the central venous catheter before and 12 hours after oper-ation to detect the serum inflammatory indexes , including tumor necrosis factor-α( TNF-α) , interleukin-6 ( IL-6) and inter-leukin-10 (IL-10), and coagulation indexes, including neutral grain of elastase, prothrombin time (PT) and activated partial thromboplastin time ( APTT) .Results The volume of drainage from pericardium and frozen plasma infusion volume of the groups A, B and C were less than that of the control group , and the combination group was less than the other groups ( all P<0.05).The serum levels of TNF-αand IL-6 in the groups A, B and C were lower than that of the control group , and group C was lower than the other two groups;the serum level of IL-10 in the groups A, B and C were higher than that of the control group, and group C was higher than the other two groups;the serum levels of elastase , PT and APTT in the groups A, B and C were lower than that of the control group , and group C was lower than the other two groups ( all P<0.05) .Conclusion The ulinastatin and aminomethylbenzoic acid have hemostatic and anti-inflammatory effect in children undergoing ventricular septal defect repair , which can reduce the volume of drainage from pericardium and frozen plasma infusion volume during the operation, and it may be related with the promotion of coagulation and inhibition of inflammatory reaction .
Keywords：ulinastatinaminomethylbenzoic acidventricular septal defectinflammationcoagulation
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 4-6 )