Preventive effect of oxytocin on post-traumatic stress disorder of rats
DONG Yuan-jun
ZHANG Yue-qi
HU Min
ZHANG Zhi-qiang
ZHANG Gui-qing
Abstract：Objective To investigate the effect of oxytocin on post-traumatic stress disorder ( PTSD) of rats.Meth-ods Twenty-four Wistar rats were randomly divided into the control group, the single prolonged stress ( SPS) group and the oxytocin ( OT) group with 8 rats each.The 14-day oxytocin intervention was given to rats after the SPS stimulation with-in 12 hours.During the intervention, the scores of bound refusing reflection were evaluated every three days.On the 16th day, the open-field test was conducted in each group to observe the crossing and the standing behaviors;on the 17th to 21st days, the Morris water maze test was done to observe the navigation capability and the space exploration ability.Results Compared with the SPS group, the scores of bound refusing reflection in the OT group decreased, the times of crossing and standing behaviors increased and the navigation capability and the space exploration ability improved, thus the differences in these two groups were significant ( all P<0.05) .Conclusions An early and timely oxytocin intervention can signifi-cantly reduce the stress-related clinical manifestations in rats and protect the injury on learning and memory ability of rats caused by stress.
Keywords：oxytocinpost-traumatic stress disordersingle prolonged stressearly intervention
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 20-22 )