Expression of platelet-derived growth factor of patients with different types of coronary heart disease and its relationship with the characteristics of ultrasound imaging of plaque

FU Guang-xue; CHEN Yu-dong

doi:10.3969/j.issn.1002-266X.2015.41.001

Abstract：Objective To explore the expression of platelet-derived growth factor ( PDGF) in patients with different types of coronary heart disease and its correlation with the characteristics of ultrasound imaging of plaque.Methods We selected 138 cases of patients with coronary angiography, including 65 patients with acute coronary syndrome (ACS), 35 patients with unstable angina ( UAP) and 30 patients with acute myocardial infarction ( AMI) , 73 patients with non-acute coronary syndrome, including 40 patients with stable angina ( SAP) and 18 patients with old myocardial infarction ( OMI) , and 15 patients with normal coronary angiography.Using double antibody sandwich enzyme-linked immunosorbent method to detect serum level of PDGF in patients.Using intravascular ultrasound was used to detect the coronary lesions of patients with ACS and SAP, and we compared the differences in the levels of serum PDGF in different plaques of patients.Results The serum PDGF concentrations in the SAP, OMI, UAP and AMI patients were higher than those of the control group (all P<0.05), the serum PDGF concentrations of the UAP and AMI patients were higher than those of the SAP and OMI patients (all P<0.05);the serum PDGF concentration of AMI patients was higher than the UAP patients (P<0.05). The coronary lesions in the SAP group were mainly hard plaques, and those of the ACS group were mainly soft plaques.The occurrence rates of ACS plaque rupture, thrombosis and positive remodeling were higher than those of SAP (all P<0.05), and the difference between SAP and ACS was statistically significant (P<0.05).The average level of PDGF in patients with fibrous plaque, calcified plaque and mixed plaque was lower than that of patients with soft plaque (all P<0.05). Conclusions PDGF is involved in the formation of coronary atherosclerotic plaque, and serum PDGF level can provide a new way for clinical diagnosis, prevention and treatment of ACS.