Systematic review of Tanreqing injection in treatment of systemic inflammatory response syndrome

WU Shan-shan; YU Qiang

doi:10.3969/j.issn.1002-266X.2015.39.032

Abstract：Objective To evaluate the efficacy of Tanreqing injection in treatment of systemic inflammatory response syndrome (SIRS) systematically.Methods We retrieved Ovid/Pubmed, Embase, CNKI, Wanfang data, VIP and Chi-nese biomedical literature database to search for the randomized controlled trial ( RCT) of Tanreqing injection in the treat-ment of SIRS , and then we observed the following indexes , including the clinical total effective rate , white blood cell count (WBC), serum C-reactive protein (CRP) and serum tumor necrosis factor-α(TNF-α), serum calcitonin (PCT) and tem-perature ( T) .According to the Jadad quality evaluation , we evaluated the literatures .Results Eleven trials were eligible finally, and contained 811 cases of patients including 396 patients treated with conventional treatment and 415 with Tan-reqing injection based on conventional treatment , only one literature was of high-quality.Meta analysis showed that the therapeutic effect of SIRS treated with Tanreqing injection was better than that treated by routine alone , and it reflected mainly in the following:the total clinical efficiency was increased (OR=3.05, 95%CI:1.46-6.39, P=0.003), the level of WBC (WMD=1.39,95%CI:2.25 to 0.53, P=0.002), the level of CRP (WMD=13.78, 95%CI:19.96 to 7.60, P<0.00 01), the level of PCT (SMD=2.17, 95%CI:4.23 to 0.11, P=0.04), the level of TNF-α(SMD=-1.50, 95%CI:2.14 to 0.85, P<0.00 001), and the level of IL-6 (WMD=-24.04,95%CI:36.03 to 12.05, P<0.00 01) were decreased, ant the level of T was decreased (WMD=-0.66, 95%CI:0.85 to 0.47, P<0.00 01).No serious adverse reactions were reported .Conclusion Tanreqing injection has good effect in treatment of SIRS .