Association between FoxO3 a gene rs2253310 polymorphisms and type 2 diabetes mellitus
DENG Lin
WANG Yu-xia
SHANG Xue-ying
Abstract：Objective To observe the gene polymorphisms of rs 2253310 in FoxO3a of patients with type 2 diabetes mellitus in Liaoning , and to investigate the relationship between the gene polymorphism of rs 2253310 and type 2 diabetes mellitus.Methods The single nucleotides polymorphism of rs 2253310 in FoxO3a of 374 cases of patients with type 2 dia-betes mellitus ( experimental group ) were detected and 283 cases of control subjects without diabetes ( control group ) .We measured the body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP) and fasting blood glucose (FBG) of different rs2253310 genotypes in patients.Results BMI, SBP, DBP and FBG in the experimental group were significantly higher than those of the control group (all P<0.05).The homozygous genotype GG was the most genotype and G gene was the most allele in FoxO 3a gene rs2253310 of the two groups .The G allele frequency and the GG genotype frequency in the experimental group were 73.4%and 54.01%, while in the control group they were 74.56%and 55.12%; there was no statistically significant difference between the two groups (all P >0.05).In the experimental group, there was no statistically significant difference in BMI , SBP, DBP and FBG in the different genotypes of rs 2253310 . Conclusion The single nucleotide polymorphisms of rs 2253310 in FoxO3a was not associated with type 2 diabetes melli-tus.
Keywords：diabetes mellitustype 2forkhead box class O3agene polymorphisms
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 13-15 )