Changes in levels of serum soluble transferrin receptor before and after high-flux hemodialysis in patients with uremia and its related factors
YIN Pei
LI Ji-jun
SONG Yan
CHEN Feng-kun
ZHANG Yi-yan
YAO Feng-hua
ZHAO Chang-zheng
Abstract：Objective To investigate the changes in levels of serum soluble transferrin receptor ( sTfR) after switc-hing from maintenance hemodialysis to high-flux hemodialysis ( HFD) in patients with uremia, and to analyze its related factors.Methods Forty patients undergoing low-flux maintenance hemodialysis were treated by high-flux maintenance he-modialysis for 12 months.The levels of sTfR, iron metabolism indices, anemia index and inflammatory index were meas-ured before HFD treatment ( T0 ) and after HFD treatment for 2 months ( T1 ) , 6 months ( T2 ) and 12 months ( T3 ) .Pear-son correlation and multiple regression method were used to analyze the relationship between serum sTfR and other indexes. At the same time, we observed the changing trend of erythropoietin and the amount of iron therapy.Results Serum sTfR level was significantly decreased at T1 , T2 and T3 as compared with that at T0 , and significant difference was found ( all P<0.01).Pearson correlation analysis showed that sTfR was positively correlated with Ret%, SF (r=0.154, 0.152;all P<0.05) and was negatively correlated with Hb, HCT, β2-MG and TBC ( r =-0.251, -0.299, -0.384 and-0.166;P<0.01 or P<0.05).Multiple regression showed that HCT, TSAT andβ2-MG levels were closed related with serum sTfR level in HFD patients (all P<0.01).The erythropoietin and iron dosage in this group reduced with prolonged HFD treatment.Conclusions HFD can effectively improve renal anemia in patients with maintenance hemodialysis.The detection of sTfR level reflects the effects of iron reserves and erythropoietic stimulation on patients.
Keywords：hemodialysishigh-flux hemodialysissoluble transferrin receptoranemia
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 4-6 )