Therapeutic effect of hyperbaric oxygen on spinal cord injury in rats and its mechanism
LIU Shi-chen
SHEN Fu-guo
YANG Jian-hua
QIAO Jian-min
JI Qing-hui
CUI Hong-yu
ZHANG Fu-yun
Abstract：Objective To observe the therapeutic effect of hyperbaric oxygen ( HBO ) on the spinal cord injury ( SCI) , and to explore its possible mechanism.Methods Twenty-five healthy and clean SD adult rats were randomly di-vided into the SCI group (n=10), HBO group (n=10) and the control group (n=5).The SCI model rats were prepared in the SCI and HBO groups, after the success of molding, the HBO group received HBO treatment;the vertebral plates of rats in the control group were opened and sutured without damage to the spinal cord.BBB rating and synaptophysinⅠmR-NA in the spinal cord tissues at different time points (6 h after molding and 1, 3, 7, 14 and 21 d, which is counted as T1 , T2 , T3 , T4 , T5 and T6 ) were observed in the two groups.Results Compared with the control group, the BBB rating and synaptophysinⅠmRNA expression was increased in the HBO group and SCI group at each time point ( T3 , T4 , T5 and T6 ) (all P<0.05).Compared with the SCI group, the BBB rating and synaptophysin Ⅰ mRNA expression was increased in the HBO group at each time point (T3, T4, T5 and T6) (all P<0.05).Conclusion HBO promoted the recovery of the injured spinal cord of rats, which may be related with the up-regulation of synaptophysin Ⅰ mRNA expression in the in-jured spinal cord tissues.
Keywords：spinal cord injuryhyperbaric oxygensynaptophysinⅠ
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 16-18 )