Clinical usefulness of measuring neutrophil-lymphocyte ratio and red blood cell distribution width in peripheral blood of patients with hepatitis B
GONG Jiao
DAI Hang
HU Bo
Abstract：Objective To observe the changes of neutrophil-lymphocyte ratio ( NLR) and red blood cell distribution width (RDW) in the peripheral blood of hepatitis B virus (HBV)-infected patients and to investigate the significance. Methods Fouty-tow patients with chronic hepatitis B (CHB, group A), 40 patients with chronic severe hepatitis B ( CSHB, group B) and 45 normal healthy persons ( control group, group C) were enrolled in this study.According to me-dian value of NLR, group B was divided into two groups:group B1 including 20 patients ( NLR≤3.51) and group B2 in-cluding 20 patients (NLR>3.51).In all subjects, a blood sample was collected at admission to examine RBC, Hb, RDW, NLR and prothrombin activity ( PTA) , which were determined using XE-5000 automated hematology analyzer and STAGO STA-R automatic coagulation analyzer.Results Compared with group C, RDW was increased, and RBC and Hb were decreased in the group A ( all P<0.05);compared with group C, RDW and NLR were increased, and RBC and Hb were decreased in the group B (all P<0.05);compared with group A, RDW and NLR were increased and PTA,RBC and Hb were decreased in the group B;and statistical difference was found (all P<0.05).Moreover, the NLR level was nega-tively correlated with PTA (r=-0.5571, P<0.5).Patients in group B2 tended to be older, and had higher NLR values as compared with those of group B1 (all P<0.05).Conclusion RDW and NLR values are increased in patients with hepatitis B and the combined detection of them helps to determine the severity and degree of liver damage.
Keywords：neutrophillymphocytesred blood cell distribution widthhepatitishepatitis B
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 5-7 )