Expression and clinical significance of miR-200a in nasopharyngeal carcinoma
LI Xiao-xue
SHI Shu-jing
YI Xiang
Abstract：Objective To observe the expression changes in levels of miR-200a in the tissues of nasopharyngeal carcinoma ( NPC) and nasopharyngitis and to analyze its relationship with the occurrence and development of NPC.Methods We took 39 cases of nasopharyngeal carcinoma tissues as the observation group and 12 cases of nasopharyngitis tissues as the control group. The real-time fluorescent quantification PCR was used to detect the expression levels of miR-200a in the two groups.The differ-ential expression levels of miR-200a in NPC patients with clinicopathological parameter ( including age, gender, T stage, N stage and clinical grade) were compared.Results The relative expression of miR-200a in the observation group and the control group was 0.539 ±0.281 and 0.744 ±0.358, respectively.The expression of miR-200a in the observation group was significantly decreased as compared with that of the control group(P<0.05).The expression of miR-200a in the observation group decreased with T stage, N stage and the increasing clinical stages (P<0.05 or P<0.01).Conclusion The expression of miR-200a in the NPC tissues is down-regulated which may participate in the pathogenesis and development of NPC.
Keywords：nasopharyngeal carcinomamiR-200areal-time fluorescent quantification polymerase chain reaction
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 14-15 )