Early diagnostic value of MDCT in acute myocardial ischemia models of mini swine

doi:10.3969/j.issn.1002-266X.2015.34.002

Abstract：Objective To determine the value of multidetector computed tomography ( MDCT) in evaluating the coro-nary artery blood flow and infarction size in the early phase of mini swine models with acute myocardial infarction.Methods Eighteen swine were randomly divided into the sham operation group ( n=6 ) and the model group ( n=12 ) .In the model group, mini swine were used to establish myocardial ischemia models by ligating LAD via thoracoscopy after coronary angiography.The 12-Lead ECG monitor was used to record the signals of swine 30 min before the experiment and after liga-tion of coronary artery.After 4 and 96 hours surgery, the ischemia models were detected by MDCT and echocardiography, respectively.At the end of the experiment, swine were sacrificed for pathological staining as well as myocardial ischemia and infarction.Results In pathological staining, no ischemia and infarction tissue and other abnormalities were found in the sham operation group.The coronary angiography results showed that the blood flow was normal but the first diagonal branch was completely interrupted after ligation of coronary artery in the model group, and MDCT coronary artery scanning showed no blood flow in left anterior distal coronary artery.Besides, the infarction size of MDCT scanning was consistent to echocardiography and Evans, TTC staining, which mainly distributed apex and left anterior ventricle and part of interven-tricular septum.Conclusion MDCT can be used to evaluate the early coronary blood flow and infarction size of acute myo-cardial infarction.