Changes in level of plasma Ghrelin in patients with rheumatoid arthritis and correlations with serum C-reactive protein, rheumatoid factor and anti-cyclic citrullinated peptide antibody
YANG Mei-hua
WANG Xiang-hong
FENG Zhong-jun
LI Li-hua
LI Hui-na
Abstract：Objective To observe the changes in level of plasma Ghrelin in patients with rheumatoid arthritis ( RA) and to investigate the correlations between it and serum C-reactive protein ( CRP) , rheumatoid factor ( RF) and anti-cyclic citrullinated peptide ( anti-CCP) antibody.Methods We recruited 105 cases of patients with RA as the RA group inclu-ding 39 cases of joint without distortion (level 1), 45 cases of mild joint deformation (level 2) and 21 cases of severe joint deformation ( level 3) , and 120 cases of healthy people as the control group.Enzyme-linked immunosorbent assay was used to detect the levels of Ghrelin and anti-CCP antibodies, the immunonephelometry was applied to detect C-reactive protein ( CRP) , the turbidimetry was used to detect the rheumatoid factor ( RF) , Westergren method was used to detect ESR, and electrical impedance was applied to detect the platelet ( PLT) .Results In the RA group, the plasma Ghrelin level was significantly lower than that of the control group (P<0.05);the more severe the degree of joint deformity, the lower of the plasma Ghrelin level, Level 3 <level 2 <level 1 (all P<0.05).In the RA group, the plasma Ghrelin level was nega-tively correlated with CRP, RF and anti-CCP antibody (r=-0.511, -0.302 and -0.527;all P<0.05).In the con-trol group, the plasma Ghrelin level was only negatively correlated with CRP (r=-0.221,P<0.05).Conclusion The plasma Ghrelin level was significant decreased in patients with RA, and it was correlated with the degree of deformation of the joints, CRP, RF and anti-CCP antibody.
Keywords：arthritisrheumatoidGhrelinC-reaction proteinrheumatoid factorsanti-cyclic citrullinated peptide antibody
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 18-20 )