Influence of antihypertensive therapy on level of plasma brain B-natriuretic peptide in elderly hypertensive patients complicated with coronary artery stenosis

HU Hui-ying; LI Zhi-gang

doi:10.3969/j.issn.1002-266X.2015.33.004

Abstract：Objective To investigate the influence of antihypertensive therapy on the level of plasma brain B-natri-uretic peptide ( BNP) in the elderly hypertensive patients complicated with coronary artery stenosis.Methods A total of 301 mild to moderate elderly hypertensive patients with blood pressure≥140/90 mmHg and 50%≤degree of coronary ar-tery stenosis <75%were selected, and they would receive percutaneous coronary intervention (PCI).According to the degree of coronary artery stenosis, they were divided into the single-vessel disease group of 118 cases double-vessel disease group of 104 cases and multi-vessel disease group of 79 cases.The systolic blood pressure, diastolic blood pressure, plas-ma BNP, left ventricular end diastolic diameter ( LVEDD) , left atrial diameter ( LAD) and left ventricular ejection fraction ( LVEF) were compared before and 6 months after antihypertensive therapy.Results The levels of systolic blood pressure and diastolic blood pressure of the three groups were significantly decreased after antihypertensive therapy for 6 months, and the difference was statistically significant ( all P<0.05) .The level of BNP was significantly increased with the increasing number of coronary artery stenosis, the level of plasma BNP declined after antihypertensive therapy for 6 months in the three groups, and the difference was statistically significant (all P<0.05).The levels of LVEDD and LAD in the multi-vessel disease group were significantly increased and LVEF was decreased as compared with those of the single-and double-vessel disease groups;the levels of LVEDD and LAD of the multi-vessel disease group were significantly decreased and LVEF was increased after antihypertensive therapy for 6 months, and the difference was statistically significant (all P<0.05).Con-clusions The antihypertensive therapy can reduce the level of plasma BNP and improve heart function in elderly hyperten-sive patients complicated with coronary artery stenosis.