Observation of gene single nucleotide polymorphisms of IFN-ω1 and IFNGR in self-limiting HBV infection and chronic HBV infection patients
WANG Ya-li
LAI Yi
LIU Yang
HU Zhang-yong
YANG Jun
DENG Lan
Abstract：Objective To observe the gene single nucleotide polymorphisms (SNPs) of interferon-ω1 (IFN-ω1) and interferon-γreceptor ( IFNGR) in self-limiting hepatitis B virus ( HBV) infection and chronic HBV infection patients. Methods PCR-RFLP was used to detect four SNP sites of IFN-ω1 and four sites of IFNGR in 206 cases of patients with self-limiting HBV infection ( control group) and 210 cases of patients with chronic HBV infection ( case group) .The geno-type and allele frequency of the two groups were compared.Results The rs9376267 gene loci CT genotype frequencies of IFNGR in the case group and control group were respectively 48.4%and 60.3%(P=0.012).No statistically significant difference was found between the two groups in the genotype and allele frequency of other SNP sites of IFN-ω1 and IFNGR genes.Conclusion The CT genotype frequency on IFNGR rs9376267 site in patients with self-limiting HBV infection was higher than that of the patients with chronic HBV infection.
Keywords：interferon-ω1interferon-γreceptorhepatitis B virus infectiongene single nucleotide polymorphism
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )