Changes in levels of ghrelin and obestatin in plasma of patients with acute coronary syndrome and the significance
SUN Xiao
ZHANG Man
WANG Shi
TONG Hao
Abstract：Objective To investigate the mechanism and significance of ghrelin and obestatin in the occurrence and development of acute coronary syndrome (ACS).Methods A total of 108 ACS patients (group A) and 30 healthy peo-ple(group B) were selected.The levels of ghrelin and obestatin in plasma were detected by radioimmunoassay , and the correlations of ghrelin and obestatin levels with the risk factors of ACS were analyzed .Results Compared with group B , the body mass index(BMI),low density lipoprotein (LDL), blood pressure, intima-media thickness(IMT)and the propor-tion of carotid plaques were significantly higher in the group A (P<0.05), the blood glucose levels increased , but it was not statistically significant .The ghrelin level was significantly lower and the obestatin level was significantly higher in the group A as compared with those of group B (all P<0.05).The G/O ratio of the group A was significantly lower than that of group B (P<0.05).Correlation analysis showed that the level of ghrelin in plasma was negatively correlated with BMI , LDL and IMT (r=-0.17,-0.31 and -0.22;all P<0.05);the level of obestatin in plasma was positively correlated with LDL and IMT(r=0.29, 0.24;all P<0.05).Conclusions The expression of plasma ghrelin and obestatin was ab-normal in ACS patients , which may participate in the occurrence and development of atherosclerosis .
Keywords：acute coronary syndromeatherosclerosisghrelinobestatincorrelation analysis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 20-22 )