Clinical and pathological features of primary central nervous system diffuse large B-cell lymphoma
CHEN Rong
HAN Jing-li
SHI Xiao-li
MA Zhi-ping
LI Xin-xia
Abstract：Objective To investigate the clinical and pathological features of primary central nervous system diffuse large B-cell lymphoma ( PCNS-DLBCL) , and to investigate survival situation.Methods We got 30 cases of tissue speci-men by surgical resection from PCNS-DLBCL patients, then observed pathological characteristics and immune phenotype by using EnVision two steps and HE staining.Univariate analysis was used to detect the relationships between prognosis and the features including age, PS score, IPI score, treatment and immune subtype.The Cox regression model analysis was used to analyze multivariate influence factors.Results The clinical manifestations were mainly intracranial high pressure and focal neurological deficits.Tumor cells mostly were centroblasts in morphology.The immune phenotype was mainly non-GCB type.Univariate analysis showed that the age, PS score, IPI score, treatment and immune subtype were statisti-cally related to the prognosis of patients (all P<0.05).Multivariate analysis showed that IPI score which was more than 2 was related to poor prognosis (P<0.05).Conclusions The clinical manifestations of PCNS-DLBCL were nonspecific, the long-term survival rate was low and the prognosis was poor.The IPI score was related to the prognosis of patients.
Keywords：lymphomalarge celldiffusecentral nervous systemimmune phenotypeprognosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-3,13 )